How Long Will We Ignore the Truth About Vitamin D?
As temperature levels decrease, prices of respiratory system infections — the acute rhinitis as well as flu, largely — raise tremendously. Many think this involves the drop in temperature level, however cool direct exposure really increases your body immune system, making you much less vulnerable to infection.
According to a 2002 research study1,2 by the U.S. as well as Canadian militaries, cool direct exposure can increase the variety of all-natural awesome (NK) cells in your body, which become part of your initial line of protection versus pathogenic seepage as well as various other kinds of cell damages.
As outlined by retired registered nurse as well as scholastic instructor John Campbell in the video clip over, a clinical testimonial3 released in 2006 ended that epidemic seasonal flu is probably pertaining to the frequency of vitamin D shortage throughout winter season. According to the writers: 4
“In 1981, R. Edgar Hope-Simpson recommended that a ‘seasonal stimulation’ thoroughly related to solar radiation clarified the amazing seasonality of epidemic flu.
Solar radiation sets off durable seasonal vitamin D manufacturing in the skin; vitamin D shortage prevails in the winter season, as well as turned on vitamin D, 1,25(OH)2D, a steroid hormonal agent, has extensive impacts on human resistance.
1,25(OH)2D serves as a body immune system modulator, protecting against extreme expression of inflammatory cytokines as well as raising the ‘oxidative ruptured’ possibility of macrophages.
Perhaps most significantly, it drastically boosts the expression of powerful anti-microbial peptides, which exist in neutrophils, monocytes, all-natural awesome cells, as well as in epithelial cells lining the respiratory system system where they play a significant function in safeguarding the lung from infection.”
Inverse Relationship Between Flu Deaths as well as UVB Exposure
While vitamin D has actually been connected to numerous health and wellness advantages, the connection in between vitamin D as well as contagious condition is specifically durable. For instance, a 2010 research study6 by Norwegian scientists located there’s an inverted connection in between UVB sunlight direct exposure — which is exactly how your body manufactures vitamin D normally — as well as flu fatalities. According to the writers: 7
“Non-pandemic flus primarily happen in the winter in pleasant areas. UVB estimations reveal that at high latitudes extremely little bit, if any type of, vitamin D is created in the skin throughout the winter season.
Even at 26°N (Okinawa) there has to do with 4 times extra UVB throughout the summertime than throughout the winter season. In exotic areas there are 2 small optimals in vitamin D photosynthesis, as well as virtually no seasonality of flu.
Pandemics might begin with a wave in an approximate period, while additional waves commonly happen the complying with winter season. Thus, it shows up that a reduced vitamin D condition might play a considerable function in a lot of flus The information sustain the theory that high fluences of UVB radiation (vitamin D degree), as happen in the summertime, act in a safety way relative to flu.”
Vitamin D Protects Against Fatal Lung Disease
Other research studies8,9,10 have actually validated the long-held idea that vitamin D safeguards versus consumption, a fatal lung condition that eliminates an approximated 1.8 million individuals worldwide yearly.11 This is greatly pertaining to vitamin D boosting antimicrobial peptides (AMPs) like cathelicidin (LL37).
In the past, consumption was dealt with by making certain people obtained lots of sunlight direct exposure. In reality Finsen was offered the Nobel Prize in 1903 for this decision. Around the turn of the 20th century routine sunlight direct exposure was one of the most reliable medical method for the therapy of consumption, however was ultimately eliminated with the advancement of anti-biotics.
A 2011 research study in Science Translational Medicine checked out the systems in charge of your immune system’s ability to ward against tuberculosis, concluding that T cells play a central role. They release a protein called interferon-g, which in turn activates the release of AMPs so your immune cells can mount an effective attack against the tuberculosis bacteria.
However, in order for this activation to occur, you have to have sufficient levels of vitamin D. In patients with low vitamin D levels, this immune response was not activated. Meanwhile, among those with adequate levels, there was an 85% reduction of colony-forming tuberculosis bacteria. As reported by UCLA: 12
“The team noted that vitamin D may help both innate and adaptive immunity, two systems that work synergistically together to fight infections. Previous research by the team found that vitamin D played a key role in the production of a molecule called cathelicidin, which helps the innate body immune system kill the consumption bacteria.
Humans are born with innate immunity, which is the preprogrammed part of the immune system. The current research findings demonstrate that vitamin D is also critical for the action of T cells, key players in adaptive immunity, a highly specialized system that humans acquire over time as they encounter different pathogens.”
More Than 80% of COVID Patients Are Vitamin D Deficient
Currently, the respiratory infection of note is of course COVID-19, and vitamin D appears to have a lot to do with your risk of this infection as well. According to a Spanish study13,14,15 published online October 27, 2020, in The Journal of Clinical Endocrinology & Metabolism, 82.2% of COVID-19 patients tested were found to be deficient in vitamin D. As reported by the authors: 16
“In COVID-19 patients, mean± SD 25OHD levels were 13.8±7.2 ng/ml, compared to 20.9 ±7.4 ng/ml in controls. 25OHD values were lower in men than in women. Vitamin D deficiency was found in 82.2% of COVID-19 cases and 47.2% of population-based controls.
25OHD inversely correlate to serum ferritin and D-dimer levels. Vitamin D deficient COVID-19 patients had a greater prevalence of hypertension and cardiovascular diseases, raised serum ferritin and troponin levels, as well as a longer length of hospital stay than those with serum 25 OHD levels ≥ 20 ng/ml.”
While this particular study failed to find a correlation between vitamin D levels and disease severity, other studies have shown patients with higher levels do tend to have milder disease. In fact, one such study17,18 found your risk of developing a severe case of, and dying from, COVID-19 virtually disappears once your vitamin D level gets above 30 ng/mL (75 nmol/L).
Other research19 looking at vitamin D and COVID-19 mortality found those with a vitamin D level between 21 ng/mL (50 nmol/L) and 29 ng/mL (75 nmol/L) had a 12.55 times higher risk of death than those with a level above 30 ng/mL. Having a level below 20 ng/mL was associated with a 19.12 times higher risk of death.
Vitamin D Lowers Your Risk of a Positive COVID-19 Test
Vitamin D has also been linked to a lower risk of testing positive for COVID-19. This, the largest observational study20 to date, looked at data for 191,779 American patients who were tested for SARS-CoV-2 between March and June 2020 and had had their vitamin D tested sometime in the preceding 12 months.
Of those with a vitamin D level below 20 ng/ml (deficiency), 12.5% tested positive for SARS-CoV-2, compared to 8.1% of those who had a vitamin D level between 30 and 34 ng/ml (adequacy) and 5.9% of those who had an optimal vitamin D level of 55 ng/ml or higher. As noted by the authors: 21
“SARS-CoV-2 positivity is strongly and inversely associated with circulating 25(OH)D levels, a relationship that persists across latitudes, races/ethnicities, both sexes, and age ranges.”
How Vitamin D Impacts COVID-19
In June 2020, I launched an information campaign about vitamin D that included the launch of a downloadable scientific report. This report, as well as a two-minute COVID risk quiz is available on StopCovidCold.com.
October 31, 2020, my review paper22 “Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity,” co-written with William Grant, Ph.D., and Dr. Carol Wagner, both of whom are part of the GrassrootsHealth expert vitamin D panel, was also published in the peer-reviewed journal Nutrients. You can read the paper for free on the journal’s website.
As noted in that paper, dark skin color, increased age, pre-existing chronic conditions and vitamin D deficiency are all features of severe COVID disease, and of these, vitamin D deficiency is the only factor that is readily and easily modifiable.
You may be able to reverse chronic disease, but that typically takes time. Optimizing your vitamin D, on the other hand, can be achieved in just a few weeks, thereby significantly lowering your risk of severe COVID-19.
In our paper, we review several of the mechanisms by which vitamin D can reduce your risk of COVID-19 and other respiratory infections, including but not limited to the following: 23
- Reducing the survival and replication of viruses24
- Reducing inflammatory cytokine production
- Maintaining endothelial integrity — Endothelial dysfunction contributes to vascular inflammation and impaired blood clotting, two hallmarks of severe COVID-19
- Increasing angiotensin-converting enzyme 2 (ACE2) concentrations, which prevents the virus from entering cells via the ACE2 receptor — ACE2 is downregulated by SARS-CoV-2 infection, and by increasing ACE2, you also avoid excessive accumulation of angiotensin II, a peptide hormone known to increase the severity of COVID-19
Vitamin D is also an important component of COVID-19 prevention and treatment for the fact that it:
- Boosts your overall immune function by modulating your innate and adaptive immune responses
- Reduces respiratory distress25
- Improves overall lung function
- Helps produce surfactants in your lungs that aid in fluid clearance26
- Lowers your risk of comorbidities associated with poor COVID-19 prognosis, including obesity,27 Type 2 diabetes,28 high blood pressure29 and heart disease30
Data from 14 observational studies — summarized in Table 1 of our paper31 — suggest that vitamin D blood levels are inversely correlated with the incidence and/or severity of COVID-19, and the evidence currently available generally satisfies Hill’s criteria for causality in a biological system.32
COVID-19 Features Related to Vitamin D Status
Our paper33 also details several features of COVID-19 that suggest vitamin D deficiency is at play. For starters, SARS-CoV-2 emerged in the winter in the northern hemisphere, and as we moved into summer, positive tests, hospitalizations and death rates fell. So, generally, COVID-19 prevalence has been inversely correlated with solar UVB doses and vitamin D production, just like seasonal influenza.
Secondly, people with darker skin have higher COVID-19 case and death rates than Caucasians. Vitamin D is produced in your skin in response to sun exposure, but the darker your skin, the more sun exposure you need in order to maintain an optimal vitamin D level. As a result, vitamin D deficiency tends to be far higher among Blacks and dark-skinned Hispanics.
Thirdly, one of the lethal hallmarks of COVID-19 is the cytokine storm that can develop in severe cases, which manifests as hyperinflammation and tissue damage. Vitamin D is known to regulate inflammatory cytokine production, thereby lowering this risk. Lastly, vitamin D is an important regulator of your immune system, and dysregulation of the immune system is a hallmark of severe COVID-19.
England to Hand Out Free Vitamin D Supplements
According to a November 28, 2020, BBC News report,34 British health officials are now recommending people take supplemental vitamin D this winter to reduce their risk of respiratory infections, including COVID-19.
Similar recommendations have been issued to the government health officials in Scotland, Wales and Northern Ireland. Unfortunately, no such recommendations have been issued in the U.S., which is why sharing this information is so important.
Senior care homes in the U.K. will receive enough vitamin D supplements to cover all residents, and people on the “clinically extremely vulnerable” list35 will have the option to get four months’ worth of free vitamin D supplements delivered to their homes starting in January 2021.
Even though the dose she recommended is 100% to 180% lower than the ideal range of 6,000 to 8,000 units per day, nevertheless chief nutritionist at Public Health England, Dr. Alison Tedstone, told the BBC: 36
“We advise that everyone, particularly the elderly, those who don’t get outside and those with dark skin, take a vitamin D supplement containing 10 micrograms (400IU) every day. This year, the advice is more important than ever with more people spending more time inside, which is why the government will be helping the clinically extremely vulnerable to get vitamin D.”
Co-Nutrients Reduce Your Vitamin D Requirement
If you cannot get enough amounts of sun exposure to maintain a vitamin D blood level of 40 ng/mL (100 nmol/L) to 60 ng/mL (150 nmol/L), a vitamin D3 supplement is highly recommended. Just remember that the most important factor here is your blood level, not the dose, so before you start, get tested so you know your baseline. This will help you determine your ideal dose, as it can vary widely from person to person.
Also remember that you can minimize your vitamin D requirement by making sure you’re also getting enough magnesium. Magnesium is required for the conversion of vitamin D into its active form,37,38,39,40 and research41 has confirmed higher magnesium intake helps reduce your risk of vitamin D deficiency by activating more of it.
A scientific review42,43 published in 2018 concluded that up to half of all Americans taking vitamin D supplements may not get significant benefit as the vitamin D simply gets stored in its inactive form, and the reason for this is because their magnesium degrees are too reduced.
Research by GrassrootsHealth reveals taking supplemental magnesium can lower your vitamin D need by 146%. Vitamin K2 is another important cofactor, and taking both magnesium and vitamin K2 can lower your vitamin D requirement by as much as 244%.44
All in all, the evidence is unmistakable: Optimizing your vitamin D can go a long way toward minimizing your chances of contracting a respiratory infection, be it the common cold, seasonal influenza or COVID-19.
Mounting evidence also demonstrates that if you do end up contracting COVID-19, having sufficient vitamin D will lower the odds of you requiring hospitalization45 as well as intensive care46,47,48,49 as it reduces the severity of the infection.50,51 As detailed earlier, vitamin D also lowers your risk of dying from COVID-19.52,53,54,55,56
I urge everyone to share this information so that we can minimize additional outbreaks. Again, if you live in the northern hemisphere, now is the time to check your vitamin D level and start taking action to raise it if you’re below 40 ng/mL (100 nmol/L). Experts recommend a vitamin D level between 40 and 60 ng/mL (100 to 150 nmol/L).
An easy and cost-effective way of measuring your vitamin D level is to order GrassrootsHealth’s vitamin D testing kit. Also, if you haven’t already visited www.stopcovidcold.com please do so now so you can take your free COVID risk test and grab a free PDF copy of my vitamin D report, which has far better graphics than what we were able to put into our Nutrients paper.
Once you know your present vitamin D level, use the GrassrootsHealth vitamin D calculator57 to determine how much vitamin D you might need to reach your target level, as well as remember that increasing your magnesium as well as vitamin K2 intake will optimize your vitamin D absorption as well as utilization.
Retest your vitamin D level in three to four months to make sure you’ve reached your target level. If you have, then you’re taking the correct dosage. If you’re still low (or have reached a level above 80 ng/mL), you’ll need to adjust your dosage accordingly as well as retest again in another three to 4 months.