Landmark Publication on Vitamin C for COVID-19

Regardless of what the mainstream media desire you to assume, lots of are beginning to recognize the fact, which is that both vitamin C (ascorbic acid) as well as vitamin D have a huge quantity of study revealing they give essential immune feature improvements, which your immune feature is your frontline protection versus all ailment, consisting of COVID-19.

As reported in the paper “Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect Against Viral Infections,” released April 23, 2020: 1

“The function nourishment plays in sustaining the body immune system is reputable. A wide range of mechanistic as well as medical information reveal that vitamins, consisting of vitamins A, B6, B12, C, D, E, as well as folate; micronutrient, consisting of zinc, iron, selenium, magnesium, as well as copper; as well as the omega-3 fats eicosapentaenoic acid as well as docosahexaenoic acid play essential as well as corresponding functions in sustaining the body immune system.

Inadequate consumption as well as condition of these nutrients prevail, bring about a decline in resistance to infections and also consequently a rise in condition worry.”

High-Dose Vitamin C Acts as an Antiviral Drug

As described in the video clip over by Dr. Andrew Saul, editor-in-chief of the Orthomolecular Medicine News Service, at very high dosages, vitamin C really works as an antiviral medication, properly suspending infections.

His Tokyo discussion, “Orthomolecular Medicine and Coronavirus Disease: Historical Basis for Nutritional Treatment,” highlights the truth that when made use of as a therapy, high dosages of vitamin C — frequently 1,000 times greater than the U.S. Recommended Dietary Allowance (RDA) — are required.

It’s a foundation of clinical scientific research that dosage influences therapy result, yet this facility isn’t approved when it involves vitamin treatment the means it is with medication treatment. Most vitamin C study has actually made use of poor, reduced dosages, which do not cause medical outcomes.

“The medical literature has ignored over 80 years of laboratory and clinical studies on high-dose ascorbate therapy,” Saul notes, including that while it’s extensively approved that vitamin C is advantageous in dealing with ailment, dispute exists over to what degree. “Moderate quantities provide effective prevention,” he states, while “large quantities are therapeutic.”

Landmark Paper Puts Vitamin C on the COVID-19 Treatment Map

While health and wellness authorities as well as conventional media have actually disregarded, otherwise straight-out opposed, making use of vitamin C as well as various other supplements in the therapy of COVID-19, pointing out absence of medical proof, we currently have a spots evaluation2 advising making use of vitamin C as an adjunctive treatment for respiratory system infections, blood poisoning as well as COVID-19.

The evaluation,3 released December 7, 2020, in the journal Nutrients, was co-written by Dr. Paul Marik that, in 2017, established a cutting-edge vitamin C-based therapy for blood poisoning. Marik is currently directing the Front Line COVID-19 Critical Care Alliance,4 which has actually established an extremely effective therapy for COVID-19.

The COVID-19 method was at first referred to as MATHEMATICS+ (a phrase based upon the essential elements of the therapy), yet after a number of tweaks as well as updates, the treatment as well as very early outpatient therapy method is currently referred to as I-MASK+5 while the health center therapy has actually been relabelled I-MATH+,6 as a result of the enhancement of the medication Ivermectin. Vitamin C continues to be a main element of this therapy, however.

(The 2 procedures7,8 are offered for download on the FLCCC Alliance web site in numerous languages. The medical as well as clinical reasoning for the I-MATH+ health center method has actually likewise been peer-reviewed as well as was released in the Journal of Intensive Care Medicine9 in mid-December 2020.) As described in the Nutrients evaluation abstract: 10

“There are restricted tested treatments for COVID-19. Vitamin C’s antioxidant, anti-inflammatory as well as immunomodulating results make it a prospective healing prospect, both for the avoidance as well as amelioration of COVID-19 infection, and also as an adjunctive treatment in the essential treatment of COVID-19.

This literary works evaluation concentrates on vitamin C shortage in respiratory system infections, consisting of COVID-19, as well as the systems of activity in contagious condition, consisting of assistance of the stress and anxiety reaction, its function in avoiding as well as dealing with colds as well as pneumonia, as well as its function in dealing with blood poisoning as well as COVID-19.

The proof to day shows that dental vitamin C (2-8 g/day) might minimize the occurrence as well as period of respiratory system infections as well as intravenous vitamin C (6-24 g/day) has actually been revealed to minimize death, critical care unit (ICU) as well as health center remains, as well as time on mechanical air flow for serious respiratory system infections …

Given the beneficial safety and security account as well as inexpensive of vitamin C, as well as the regularity of vitamin C shortage in respiratory system infections, it might be beneficial screening clients’ vitamin C condition as well as treating them appropriately with intravenous management within ICUs as well as dental management in hospitalized individuals with COVID-19.”

International Vitamin C Campaign Launched

In a December 16, 2020, activity alert,11 Rob Verkerk, Ph.D., creator as well as clinical supervisor of the Alliance for Natural Health, revealed the launch of a global vitamin C project12 in reaction to the spots evaluation, which “puts all the arguments and science in one, neat place.”

As kept in mind by Verkerk, there are a number of factors to take supplementary vitamin C. First, your body cannot make it. Second, many people do not obtain enough quantities from their diet regimen as well as, 3rd, your body’s demand for vitamin C can raise 10-fold whenever your body immune system is tested by an infection, condition or physical injury.

In truth, the Nutrients evaluation13 mentions that it prevails for hospitalized clients to have obvious vitamin C shortage, specified as a blood degree at or listed below 11 µmol/L. This is specifically real for older clients as well as those hospitalized for respiratory system infections.

According to the writers, “Vitamin C concentrations are three to 10 times higher in the adrenal glands than in any other organ. It is released from the adrenal cortex under conditions of physiological stress (ACTH stimulation), including viral exposure, raising plasma levels fivefold.” In his activity alert, Verkerk notes: 14

“Taking vitamin C as a preventative and afterwards, upping your consumption if you’re contaminated, is a no brainer. So is utilizing vitamin C intravenously for those with severe respiratory system infections, or blood poisoning, in essential treatment.

So a lot so, that we suggest — offered the currently offered proof — that medical professionals as well as various other health and wellness experts that prevent referrals on vitamin C in connection with COVID condition avoidance as well as therapy, need to be taken into consideration clinically irresponsible …

There is sufficient proof to reveal that supplements like zinc, vitamin C, as well as vitamin D can aid stop as well as deal with COVID-19, yet we’re stopped from discovering these advantages by the federal government.

Because supplements are not, as well as can never ever come to be, FDA-approved, they cannot assert to have an effect on condition, also when we understand they can. This rubbish needs to quit.”

How Vitamin C Works

As pointed out, the Nutrients evaluation15 information vitamin C’s systems of activity as well as just how it assists in instances of contagious condition, consisting of the cold, pneumonia, blood poisoning as well as COVID-19. For beginners, vitamin C has the adhering to fundamental buildings:

  • Anti-inflammatory
  • Immunomodulatory
  • Antioxidant
  • Antithrombotic
  • Antiviral

Beneficial antiviral results relate to both the natural as well as flexible body immune systems. When you have an infection, vitamin C enhances your immune feature partially by advertising the advancement as well as growth of T-lymphocytes, a sort of leukocyte that is an important part of your body immune system.

Phagocytes, immune cells that eliminate pathogenic microorganisms, are likewise able to absorb oxidized vitamin C as well as regrow it to ascorbic acid. With respect to COVID-19 particularly, vitamin C: 16

Helps downregulate inflammatory cytokines, therefore lowering the danger of a cytokine tornado. It likewise lowers swelling with the activation of NF-κB as well as by enhancing superoxide dismutase, catalase as well as glutathione. Epigenetically, vitamin C manages genetics associated with the upregulation of antioxidant healthy proteins as well as downregulation of proinflammatory cytokines

Protects your endothelium from oxidant injury

Helps repair service harmed cells

Upregulates expression of Type-1 interferons, your main antiviral defense reaction, which SARS-CoV-2 downregulates

Eliminates ACE2 upregulation generated by IL-7. This is specifically notable, as the ACE2 receptor is the entrance factor for SARS-CoV-2 (the infection’ spike healthy protein binds to ACE2)

Appears to be an effective prevention of Mpro, a vital protease (enzyme) in SARS-CoV-2 that turns on viral nonstructural healthy proteins

Regulates neutrophil extracellular catch development (NETosis), a maladaptive reaction that leads to cells damages as well as body organ failing

Enhances lung epithelial obstacle feature in a pet version of blood poisoning by advertising epigenetic as well as transcriptional expression of protein-channels at the alveolar capillary membrane layer that control alveolar liquid clearance

Mediates the adrenocortical stress and anxiety reaction, specifically in blood poisoning

The chart listed below, from the Nutrients evaluation, highlights the essential methods which vitamin C alleviates the pathology seen in COVID-19.

Nebulized Peroxide May Be Even Better

The gorgeous visuals over makes it truly clear that of the main manner ins which vitamin C functions is with the generation of responsive oxygen types. Guess what the main one is? If you thought hydrogen peroxide provide on your own a high 5!

It is extremely most likely that the peroxide creates an extremely effective signaling feature that boosts the body immune system to beat whatever viral hazard it is revealed to. This is just one of the reasons nebulized peroxide is my outright favored treatment for severe viral diseases. It is extremely reliable, cost-effective as well as has no negative effects when made use of at the extremely reduced dosages advised (0.1%, which is 30 times much less focused than routine pharmacy 3% peroxide).

My video clip listed below goes over the information of just how you can utilize this treatment. The trick is to have your nebulizer currently bought as well as prepared to go to ensure that it is secured as well as filled as well as you do not need to go out as well as acquire anything if you or an enjoyed one gets ill. You can still make use of vitamin C with the peroxide, as they likely have an effective harmony as well as make use of various free systems.

Since you are not utilizing complete toughness 3% peroxide as well as weakening it by 30 to 50 times, it is not likely the stabilizers will certainly provide a trouble, yet to be secure, it is best to make use of FOOD-GRADE peroxide. Also, do not weaken it with simple water as the absence of electrolytes in the water can harm your lungs if you nebulize it. Instead, usage saline or include a percentage of salt to the water to remove this danger.

peroxide dilution charts

Clinical Evidence

The Nutrients evaluation17 likewise consists of medical proof for the function of vitamin C in COVID-19, keeping in mind that very early dental supplements may aid stop a light instance from turning into something a lot more major. In clients with essential signs and symptoms, intravenous management of vitamin C has actually been revealed to quicken healing, lowering both ICU remains as well as death.

Interestingly, vitamin C shortage as well as COVID-19 share most of the exact same danger aspects, consisting of male sex, darker skin, older age as well as comorbidities such as diabetic issues, hypertension as well as COPD. All of these subgroups go to enhanced danger for serious COVID-19 as well as, according to the writers, all “have also been shown to have lower serum vitamin C levels.”

Commenting on the medical proof sustaining making use of vitamin C in the therapy of COVID-19, the writers create: 18

“There are presently 45 tests signed up on checking out vitamin C with or without various other therapies for COVID-19. In the very first RCT to evaluate the worth of vitamin C in seriously unwell COVID-19 clients, 54 aerated clients in Wuhan, China, were treated with a sugar pill (sterilized water) or intravenous vitamin C at a dosage of 24 g/day for 7 days …

The a lot more badly unwell clients with COUCH [sequential organ failure assessment] ratings ≥ 3 in the vitamin C team showed a decrease in 28-day death: 18% versus 50% in univariate survival evaluation (Figure 2). No study-related damaging occasions were reported.”

Figure 2 listed below, from variation 1 of the research study,19 “High-Dose Vitamin C Infusion for the Treatment of Critically Ill COVID-19,” published on the preprint web server Research Square August 10, 2020 (upgraded September 23, whereupon it was relabelled20), reveals the 28-day death prices in between seriously unwell COVID-19 clients offered high-dose IV vitamin C (HDIVC) contrasted to those offered a sugar pill.

28 day mortality rates

The Nutrient evaluation likewise sums up searchings for from various other COVID-19 tests utilizing vitamin C, in addition to a couple of instance records: 21

“In the UK, the Chelsea as well as Westminster health center ICU, where grown-up ICU clients were carried out 1 g of intravenous vitamin C every 12 h along with anticoagulants, has actually reported 29% death, contrasted to the ordinary 41% reported by the Intensive Care National Audit as well as Research Centre (ICNARC) for all UK ICUs …

The Frontline COVID-19 Critical Care Expert Group (FLCCC), a team of emergency situation medication specialists, have actually reported that, with the incorporated use 6 g/day intravenous vitamin C (1.5 g every 6 h), plus steroids as well as anticoagulants, death was 5% in 2 ICUs in the United States (United Memorial Hospital in Houston, Texas, as well as Norfolk General Hospital in Norfolk, Virginia), the most affordable death prices in their particular areas.

A situation record of 17 COVID-19 clients that were offered 1 g of intravenous vitamin C every 8 h for 3 days reported a death price of 12% with 18% prices of intubation as well as mechanical air flow as well as a substantial decline in inflammatory pens, consisting of ferritin as well as D-dimer, as well as a fad in the direction of reducing FiO2 needs.

Another instance of unforeseen healing adhering to high-dose intravenous vitamin C has actually likewise been reported. While these instance records go through confounding as well as are not appearing proof of results, they do highlight the expediency of utilizing vitamin C for COVID-19 without any damaging results reported.”

How Much Vitamin C Do You Need?

As outlined in the intro of the Nutrients evaluation,22 primates as well as human beings hinge on a sufficient supply of vitamin C from vegetables and fruits. Gorillas require 4.5 grams a day, while smaller sized primates evaluating around 7.5 kilos require regarding 600 mg daily. This provides us an idea regarding what the human demand could be, as well as it’s a fair bit more than the day-to-day advised consumption. According to the writers: 23

“The EU Average Requirement of 90 mg/day for guys as well as 80 mg/day for ladies is to preserve a typical plasma degree of 50 µmol/L, which is the mean plasma degree in UK grownups. This suffices to avoid scurvy yet might be poor when an individual is under viral direct exposure as well as physical stress and anxiety.

An skilled panel together with the Swiss Society of Nutrition advised that every person supplement with 200 mg ‘to load the nutrient space for the basic populace as well as specifically for the grownups age 65 as well as older. This supplement is targeted to enhance the body immune system.’ The Linus Pauling Institute advises 400 mg for older grownups (>half a century old).

Pharmacokinetic research studies in healthy and balanced volunteers sustain a 200-mg day-to-day dosage to create a plasma degree of circa 70 to 90 µmol/L. Complete plasma saturation takes place in between 1 g day-to-day as well as 3 g every 4 hrs, being the highest possible endured dental dosage, offering a forecasted height plasma focus of circa 220 µmol/L.

The exact same dosage offered intravenously increases plasma vitamin C degrees roughly significantly. Higher consumption of vitamin C are most likely to be required throughout viral infections with 2–3 g/day called for to preserve typical plasma degrees in between 60 as well as 80 µmol/L. Whether greater plasma degrees have fringe benefit is yet to be established, yet would certainly follow the outcomes of the medical tests gone over in this evaluation.”

While high-dose vitamin C routines normally require intravenous management, if dealing with a viral infection in your home (be it COVID-19 or another thing), you can make use of dental liposomal vitamin C, as this permits you to take much greater dosages without creating loosened feceses.

You can use up to 100 grams of liposomal vitamin C without troubles as well as obtain truly high blood degrees, equal to or more than intravenous vitamin C. I see that as a severe therapy, nevertheless. I inhibit individuals from taking huge dosages of vitamin C often if they’re not really unwell, due to the fact that it is basically a medication — or at the very least it functions like one.

Saul, that has actually dealt with as well as advised vitamin C for a lot of his expert life recommends taking “enough vitamin C to be symptom-free,” whatever dose that could be. When you’re well, you normally do not require greater than the 200 mg to 400 mg advised in the quote over.